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British Journal of Anaesthesia, 1985, Vol. 57, No. 6 624-628
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

NITROUS OXIDE INHALATION DOES NOT INFLUENCE PLASMA CONCENTRATIONS OF (3-ENDORPHIN OR MET-ENKEPHALIN-LIKE IMMUNOREACTIVITY

S. F. EVANS, M.B., F.F.A.R.C.S.*, M. STRINGER, B.SC., M. D. G. BUKHT, M.B., F.F.A.R.C.S., W. A. THOMAS, M.B., F.F.A.R.C.S. and S. J. TOMLIN

Department of Anaesthesia St Bartholomew's Hospital, West Smithfield, London EC1A 7BE
Department of Chemical Endocrinology St Bartholomew's Hospital, West Smithfield, London EC1A 7BE

Correspondence to M.D.G.B.

The possibility that nitrous oxide releases endogenous opioid peptides into the circulation has been tested in 10 pain-free, unstressed volunteers breathing 30% nitrous oxide in oxygen. Despite achieving plateau concentrations in venous blood, accompanied by subjective effects, there were no significant changes in plasma concentrations of immunoreactive ß-endorphin, methionine-enkephalin or ACTH. These results indicate that, in the absence of nociceptive input, the effects of the inhalation of nitrous oxide are unrelated to alterations in peripheral concentrations of these endogenous opioid peptides.

*Present address: Hospital for Sick Children, Melbourne, Australia.


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