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British Journal of Anaesthesia, 1985, Vol. 57, No. 6 621-623
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

NITROUS OXIDE AND WOUND HEALING*

T. A. ALIGIE, F.F.A.R.C.S., A. SETH, F.F.A.R.C.S., J. C. BARBENEL, M.SC., PH.D., D. J. GALLOWAY, F.R.C.S., W. M. GRAY, B.SC., PH.D. and A. A. SPENCE, M.D., F.F.A.R.C.S., F.R.C.P.GLAS.

Department of Anaesthesia, Western Infirmary Glasgow
Bioengineeing Unit, Wolfson Centre University of Strathclyde Glasgow
University Department of Surgery, Western Infirmary Glasgow
Department of Clinical Physics and Bioengineering 11 West Graham Street, Glasgow
University of Department of Anaesthesia Western Infirmary, Glasgow

Following a paravertebral surgical incision, mature, female rats under ether anaesthesia were exposed to either 3% nitrous oxide, continuously for 48 h, or 50% nitrous oxide, 4 h each day for 7 days. For each exposure group, a similar number of rats was exposed to atmospheres containing no nitrous oxide. Wound healing was assessed by measurement of the breaking strengths of wound samples. No statistically significant influence on breaking strength could be attributed to nitrous oxide following either exposure sequence.

* A preliminary account of this work was presented to the Anaesthetic Research Society in November 1983.


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